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Title   진행위암환자에 대한 5-FU , Adriamycin 과 Mitomycin - C ( FAM ) 및 Etoposide , Adriamycin 과 Cisplatin ( EAP ) 복합화학요법의 비교연구 ( FAM Versus Etoposide , Adriamycin , and Cisplatin : A Random Assignment Trial in Advanced Gastric Cancer )
Publicationinfo   1993 Jan; 025(04): 461-468.
Key_word   Advanced gastric adenocarcinoma, Chemotherapy, FAM, EAP
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Abstract   Gastric cancer is the most common malignancy in Korea. Cure for patients with gastric carcinoma can be achieved only in complete surgical resection. Despite the availsbility of radical surgical procedures, the majority of patients with this disease have poor prognosis. Therefore, the development of effective systemic therapy is essential if the outcome for patients with gastric cancer is to be improved. Preusser et al from Germany reported their experience in treatment of 67 patients with advanced gastric adenocarcinoma with etoposide, doxorubicin, and cisplatin(EAP) combination chemotherapy. Responses were observed in 43 of 67(64%) patients in which 14(21%) complete responses were included. Between February 199J and September 1992, 63 previously untreated patients with advanced gastric adenocarcinoma were randomly assigned to receive either FAM regimen(S-FU, adriamycin, and mitomycin-C) or EAP regimen(etoposide, adriamycin, and cisplatin). In 56 evaluable patients(27 for FAM snd 29 for EAP), the response rates were 33%(FAM) and 3% (EAP). The median duration of remission were 13 weeks(FAM) and 57 weeks in one responder (EAP). The median survival times were 37 weeks(FAM) and 28 weeks(KAP). The difference in the survival curves for two regimens was not statistically significant. Non-hematologic toxicities were more frequently observed in EAP regimen, but hematologic toxicities were mild and similar in the two groups. These results suggest that EAP regimen is not superior to FAM regimen in the treatment of advanced gastric cancer.
저 자   이정애(Jung Ae Rhee),윤성수(Sung Soo Yoon),양성현(Sung Hyun Yang),김시영(Si Young Kim),허대석(Dae Seog Heo),방영주(Yung Jue Bang),조경삼(Kyung Sam Cho),김노경(Noe Kyeong Kim)